It is by far known that medicines are integral components of a healthcare system. Although there are immense active pharmaceutical entities in the global market, limiting medicines that shall be used within a given health institution in accordance with the availability of professionals is advantageous for proper management of medicine with in a facility. This is done with due regard to factors like; safety, efficacy, quality, cost- benefit ratio, sufficient experience with the medicines and other factors. Pharmacotherapeutic classification of medicines was utilized to categorize medicines for the Community Pharmacy. The fourth edition of the List of Medicines for Community pharmacy is now revised in light of the latest development in the fields of medicine and pharmacy. Besides to this the Authority included some of medicine which was requested to be included in the third edition. As customary, the purpose of the fourth edition of List of Medicine for Community Pharmacy is to provide up-to-date list of medicine for the retail pharmacy, to improve procurement, to increase availability and to promote proper use of Medicines. The draft of the revised edition was first prepared by the Authority using a technical working group composed of different health professionals and then enriched through national consultative workshops. Participants involved in the workshops were specialists, health professionals from various disciplines, representatives of teaching institutions, professional associations, regional health bureaus, relevant departments of Ministry of Health, pharmaceutical manufacturers & importers, government hospitals and other related organizations. Soon after, the revised version of List of Medicine for Community pharmacy was finalized by the Authority. In the course of reviewing the previous edition, medicines which are obsolete, less effective, with low benefit to risk ratio and superseded by better ones have been deleted while medicines with better quality, safety and efficacy profile have been included. Except for the addition of some new categories, the pharmacotherapeutic classification system that was used in the previous edition is still maintained. Since the process of revising List of Medicines for Community Pharmacy is a continuous process which takes into accounts change priorities for public health actions, epidemiological conditions as well as progress in pharmacological and pharmaceutical findings, this list will be subjected to continuous revision. Consequently, all users of this list are strongly invited to send their comments and suggestions to the Food, Medicine and Healthcare Administration and Control Authority of Ethiopia, P.O. Box 5681, Tel: 251-11 552 41 22, Email: firstname.lastname@example.org, web site:www.fmhaca.gov.et Addis Ababa, Ethiopia.